Any discussion of the role of the HSPB8-BAG3-HSP70 complex in facilitating autophagy in the heart or the brain is not complete without an introduction to a new area of great interest and potential therapeutic use: stress granules [37]—stress granules (SGs) are membrane-less cytosolic assemblies that form in response to stress and have been associated with diseases as diverse as hearing loss, neurodegenerative disease, and heart failure [38]. Here, HSPB8 is linked to heart failure.