That genetic variants in BAG3 could result in more traditional heart failure as evidenced by cardiac dilatation and diminished ejection fractions was first noted by Ellinor and colleagues who identified a locus on chromosome 10 that was informative for the development of HFrEF in a large cohort of patients with dilated cardiomyopathy [85]. This evidence concerns the gene BAG3 and dilated cardiomyopathy.