Activation of apoptosis triggered by the Fas/Fas ligand interaction can be mediated by molecules which are involved in the pathology of vitiligo including CD8+ T cells, the TNF-α/TNR receptor (TNFR) pathway, the IFN-γ signaling pathway, and the CXCL10/CXCR3B pathway [52,55,92]. The gene discussed is TNFRSF1A; the disease is vitiligo.