TCGA methylation data from white blood cells revealed that ZNF154 locus remains unmethylated, even in older individuals, showing the potential for the development of a blood test for cancer detection.AUC values ranged from 0.75 to 0.87 for discriminating cancer patients from healthy individuals, except for liver cancer which displayed an AUC of 0.48. This evidence concerns the gene ZNF154 and liver cancer.