TCGA methylation data mining identified differentially methylated regions (DMRs) in the SST gene. 7 CpG sites were shown to be hypermethylated in all 3 cancers. A combination of 2 CpGs (+18 and +129) displayed the best AUC of 0.698, with 59.3% sensitivity and 72.8% specificity for detecting the 3 gastrointestinal cancers. The gene discussed is SST; the disease is cancer.