Using RNA-seq and methylation data from TCGA, identified 9 epigenetically regulated lncRNAs (lncRNAs regulated by methylation) that can predict cancer. Developed a score based on expression and methylation data of these 9 genes (PVT1, PSMD5-AS1, FAM83H-AS1, MIR4458HG, HCP5, GAS5, CTD2201E18.3, HCG11, and AC016747.3) that was applied to all cancer and normal samples. AUC values ranged from 0.741 to 0.992 for detecting 8 cancer types. AUC values ranged from 0.712 to 1 in an independent validation set. Here, PSMD5 is linked to cancer.