MMP11 and MMP13 expression was significantly higher in most cancer types compared to tissue matched controls.Each cancer type featured at least one MMP with an AUC greater than 0.9, except prostate cancer; 6 cancer types featured 4 or more MMPs with AUC > 0.9.If serum detection is possible, upregulated MMP11 or MMP13 could serve as a multi-cancer biomarker. Here, MMP11 is linked to Familial prostate cancer.