Developed EAGLING, a model that expands the Illumina 450K array data to cover about 30% of CpGs in the genome. Used this expanded methylation data combined with gene expression and somatic mutation data to identify genes with differential patterns in various cancer types (triple-evidenced genes).Developed a machine learning algorithm, using the identified triple-evidenced genes, for cancer detection. AUC of 0.85 was obtained; 95.3% accuracy was obtained for TOO discrimination. TNXB, RRM2, CELSR3, SLC16A3, FANCI, MMP9, MMP11, SIK1, and TRIM59 showed great capacity for cancer diagnosis. Here, TNXB is linked to cancer.