SHC1 and cancer: SHC1 expression was significantly upregulated in most cancers compared with normal tissues.SHC1 displayed high diagnostic value (AUC > 0.90) for 4 cancer types and moderate diagnostic value (AUC > 0.70) in 16 cancer types.Strong diagnostic capability for KICH (AUC = 0.92), LIHC (AUC = 0.95), and PAAD (AUC = 0.95).