While performing genome-wide methylation analysis for pancreatic cancer biomarker discovery, identified SST as hypermethylated in pancreatic tumors compared to normal tissue and showed an AUC of 0.89 for pancreatic cancer detection in cfDNA. SST methylation and expression in 11 other cancer types showed significant hypermethylation and downregulation of expression when compared to the respective normal tissue (p < 0.0001). The gene discussed is SST; the disease is cancer.