Identified differentially expressed genes (DEGs) that were shared in various cancer types and constructed a diagnostic model using 10 upregulated DEGs (CCNA2, CDK1, CCNB1, CDC20, TOP2A, BUB1B, AURKB, NCAPG, CDC45, and TTK).AUC of 0.894 was obtained for discriminating cancer from normal samples. The gene discussed is AURKB; the disease is cancer.