MMP11 and MMP13 expression was significantly higher in most cancer types compared to tissue matched controls.Each cancer type featured at least one MMP with an AUC greater than 0.9, except prostate cancer; 6 cancer types featured 4 or more MMPs with AUC > 0.9.If serum detection is possible, upregulated MMP11 or MMP13 could serve as a multi-cancer biomarker. The gene discussed is MMP13; the disease is prostate carcinoma.