This study demonstrated that C9orf72-ALS was associated with reduced glucose metabolism in the peri-rolandic region, extending to the precuneus, and the right thalamus, as well as increased glucose metabolism in the brainstem (i.e., medulla, extending to the pons), in relation to the C9orf72-matchedsALS group (Figure 3; Table S5). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.