MAGEA3 and cancer: While it is now recognised that the reduction of autophagy could be vital in the transition of cells from “normal” to “cancer” [164], with the study on MAGE-A3/6 an example of this, it is also widely acknowledged that autophagy sustains metabolism in cancer cells under stress and the upregulation of autophagy in malignant cells provides some form of protection for cancer cells to therapy.