TNF and asthma: In our model, we also observed the production of epithelial-derived innate cytokines, that in addition to Th2 cytokines, make a great contribution to the inflammatory response in asthma, such as IL-1β (Figure 7A), IL-6 (Figure 7B), and TNF-α (Figure 7C), the latter being considered a marker of neutrophilic asthma [29].