Recently, a significant association was demonstrated between Grave’s ophthalmopathy and HLA-A*01:01, HLA-A*32:01, HLA-B*37:01, HLA-B*39:01, HLA-B*42:01, HLA-C*08:02, HLA-C*03:02, HLA-DRB1*03:01, HLA-DRB1*14:01, and HLA-DQB1*02:01, while HLA-C*04:01, HLA-C*03:04, HLA-C*07:02, and HLA-DRB1*15:02 were shown to be protective alleles [70]. The gene discussed is HLA-C; the disease is Graves ophthalmopathy.