ChIP-on-chip data revealed that heparanase bound to regulatory regions of myeloma-related genes (i.e., CXCL12) [57], encodes for SDF-1, CXCR4, CXCL2, CXCR3, CCL27, CX3CL1, and LCN2 [58,59,60]. Here, CXCL2 is linked to plasma cell myeloma.