Therefore, in this study, we used Sdc-1 knockdown and overexpression approaches in breast cancer cell lines in vitro to elucidate the regulatory and signaling pathways associated with the Sdc-1/TF/coagulation axis, to study its impact on further cellular properties including cell cycle progression and cell motility, and to analyze its consequences for platelet activation. The gene discussed is SDC1; the disease is breast cancer.