Based on previous findings showing that Sdc-1-KD negatively affected angiogenesis in a TF pathway-dependent manner in a breast cancer cell–endothelial cell co-culture model [11], we present here, to the best of our knowledge, the first functional link between Sdc-1 and different components of the TF pathway in the context of breast cancer progression. The gene discussed is SDC1; the disease is breast carcinoma.