SDC1 and ductal breast carcinoma in situ: For example, Sdc-1 expression is associated with angiogenic factors in ductal breast carcinoma in situ, its interaction with αvβ3 and αvβ5 integrins regulated angiogenesis in a murine breast cancer model, and Sdc-1 expression by stromal fibroblasts enhances tumor growth and angiogenesis [6,9,10].