As opposed to statistically significant upregulation in adrenocortical carcinoma, glioblastoma, skin cutaneous melanoma, thyroid, and endometrial cancer, TNK2 expression is downregulated in acute myeloid leukemia (AML), pancreatic cancer, and pheochromocytoma compared to the corresponding healthy tissues (Figure 5B). This evidence concerns the gene TNK2 and familial pancreatic carcinoma.