Figure 4A shows that the frequency of total blood CD8 T cells was around 35% of total T lymphocytes and was similar for both HCMV+ HD with or without HCMV-specific CD8 T cells detected in our experimental conditions. The mean value for CD4/CD8 ratio was found >1 for all the subjects, ranging from 0.42% to 4.69% for HD with detectable HCMV-specific CD8 T cells and from 0.41% to 5.85% for HD without detectable HCMV-specific CD8 T cells (Figure 4B), thus indicating no CD8 T inflation, but rather a normal homeostasis of T cells. Here, CD4 is linked to Huntington disease.