The effectiveness of ecto-5′-nucleotidase (CD73) is ensured by the activation of cell-surface adenosine receptors (A1AR, A2AAR, A2BAR, A3AR); it is effective not only in the liver but also in cases of myocardial ischemia; so, 5′-nucleotidase or A2BAR agonists can be used as therapy for myocardial ischemia [71]. Here, NT5E is linked to myocardial ischemia.