Similarly, we found a notable enrichment of hematopoiesis/angiogenesis-related proteins (e.g., ARPC5, CA2, CDC42, EMILIN1, HBG1, HNRNPA1, HNRNPA3, LTBP1, MPO, VASP), specifically of those associated with anemia/hypoxia (e.g., ANK1, EPB42, SLC4A1, SPTA1) in the proteins being positively associated with AS phenotype. The gene discussed is CA2; the disease is anemia.