We observed the activation of the cholesterol biosynthesis, LXR/RXR and PPAR signaling pathways (Figure 2C and Figure S3); and the repression of the sirtuin, matrix metalloprotease, acute phase response, osteoarthritis, hepatic fibrosis and TGFβ signaling pathways (Figure 2B and Figure S3). The gene discussed is TGFB1; the disease is osteoarthritis.