This inverse correlation between miR-32-5p and PTEN has been confirmed in HCC cell lines and patients, and it has been found that miR-32-5p can also transfer to other liver cancer cells without 5-FU resistance through exosome, leading to an increase in miR 32-5p, a decrease in PTEN, and activation of the PI3K/Akt pathway, finally inducing 5-FU resistance [91]. This evidence concerns the gene PTEN and hepatocellular carcinoma.