The association between metabolic alterations and sorafenib resistance in HCC cells, together with the demonstrated importance of CXCR3 in the development of resistance to sorafenib in HCC cells and the novel mechanism of CXCR3 regulation of the AMPK pathway activity and adipocytokine signaling, suggest that lipid peroxidation results in metabolic alterations during chemoresistance [111]. The gene discussed is CXCR3; the disease is hepatocellular carcinoma.