AKT1 and hepatocellular carcinoma: This upregulation of the PTEN-PI3K/AKT pathway by elevated lncARSR expression underlies doxorubicin resistance in HCC, as evidenced by the fact that inhibition of the PI3K/AKT pathway abolishes lncARSR-dependent doxorubicin resistance in HCC cells, and depletion of PTEN reverses the effects of lncARSR knockdown on doxorubicin resistance in HCC cells [71].