Accordingly, we have demonstrated that Eomes+ Th cells infiltrated the CNS during disease in mouse models of amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) where they can secrete neurotoxic granzyme B after encounter with ectopically expressed ORF1 antigen encoded by L1 retrotransposon [25]. This evidence concerns the gene GZMB and early-onset autosomal dominant Alzheimer disease.