We have recently demonstrated that Eomes+ Th cells infiltrated into the CNS of mouse models of amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) secrete neurotoxic granzyme B after encounter with ectopically expressed ORF1 antigen encoded by L1 retrotransposon [25]. Here, GZMB is linked to early-onset autosomal dominant Alzheimer disease.