Based on 14 pairs of iCCA tumors and non-tumor liver tissue samples, these iCCA tumors can be divided into S100P+SPP1− and S100P−SPP1+ groups, which not only represent two different origins of iCCA, one from the peripheral large and another from the small duct, but also different biological functionals. The gene discussed is S100P; the disease is infantile convulsions and choreoathetosis.