Lactate dehydrogenase A (LDHA) converts lactate in pyruvate, and its inhibition impairs invasion and migration in in vitro assays of renal cell carcinoma (RCC), pancreatic cancer and prostate cancer—and decreased metastasis in an orthotopic renal xenograft model [123,124,125]. The gene discussed is LDHA; the disease is familial pancreatic carcinoma.