A recent study from our group demonstrated that NLRP7 should not only be considered as the most mutated gene responsible for recurrent CHM, the benign tumor of the placenta that develops into GC in 5–20% of cases but also as an important factor in the etiology of GC, through its direct biological actions on the growth and aggressiveness of GC tumors [2]. Here, NLRP7 is linked to benign neoplasm.