Importantly, it has been demonstrated that NLRP2 knockdown in the trophoblastic tumor cell line, JEG-3, causes a significant increase in NF-κB p65 Ser 536 phosphorylation [16] and that this protein has the ability to inhibit the ASC-dependent activity of NF-κB (Radian et al. 2013, Kinoshita et al. 2005). This evidence concerns the gene NFKB1 and neoplasm.