The CD8+TIM-3+, CD8+TIGIT+TIM-3+, CD8+TIGIT-TIM-3+, and CD8+TIGIT-TIM-3− subpopulations were found more frequently in melanoma patients compared to the control group, while CD8+TIGIT+TIM-3− presented an opposite pattern. The gene discussed is HAVCR2; the disease is melanoma.