SERPIND1 and Insulin resistance: The level of heparin cofactor-II in subjects with PCOS was shown to be increased [63]; however, in a multivariate analysis where BMI, inflammation, and insulin resistance were accounted for, no correlation of PCOS with either heparin cofactor II or any coagulation proteins was seen, suggesting that hypercoagulability is not an intrinsic facet of PCOS.