SIRT5 and heart failure: The comparison of transgenic SIRT5-overexpressing, SIRT5 KO, and wild-type mice in which cardiac hypertrophy and heart failure (HF) were induced by transverse aortic constriction (TAC) has revealed that an increase in SIRT5 deacylase activity is associated with an improvement in cardiac function and a decrease in fibrosis during pressure overload [96].