Once they reach the tumor site, TAN release different factors such as MMP-8, MMP-9, CXCL1, CXCL2, CXCL6, CXCL8, CCL7 and VEGF, which have been described to be highly involved in CCA biology [9] (Figure 4). The gene discussed is CXCL2; the disease is neoplasm.