In cancer, CAFs promote new blood vessel formation and metastasis by enhancing immune-cell infiltration through the release of several cytokines and chemokines such as stromal cell-derived factor 1 (SDF-1) and IL-6, and by secreting several growth factors including endothelial growth factor, hepatocyte growth factor (HGF) and epidermal growth factor (EGF) [11,123]. This evidence concerns the gene CXCL12 and cancer.