PSMB8 and proteosome-associated autoinflammatory syndrome: PRAAS span the disease spectrum, ranging from chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) to joint contractures, muscle atrophy, microcytic anemia and panniculitis-induced lipodystrophy (JMP), Nakajo-Nishimura syndrome (NNS) and Japanese autoinflammatory syndrome with lipodystrophy (JASL), which are autoinflammatory syndromes mainly caused by genetic mutations in the immunoproteasome subunit β5i (encoded by PSMB8) [18,27,28,29,30,31,32,33].