Interestingly, TCIRG1 is a T-cell immunoregulator, being essential in T-cell activation and differentiation, and its expression is increased in GBM, where it is used as an indicator of lymphocyte infiltration [35] YKL40 is associated with inflammation, proliferation, and angiogenesis [43,44,45]. Here, TCIRG1 is linked to glioblastoma.