Our results show that just 24 h after the injection, CFA dysregulated key signaling pathways linked to RA pathogenesis, including MAPK [41], Jak-STAT [42], HIF [43], PI3K-Akt [44], TLR [45], TNF [46], and NF-kB [47]. Here, NFKB1 is linked to rheumatoid arthritis.