AKT1 and cancer: In this neuronal stream, tumors produced a large number of chemokines that, binding their receptors, directly favor cancer cell expansion through diverse signaling pathways such as the phosphatidylinositol-3 kinase/AKT/nuclear factor kappa B (PI3K/AKT/NF-κB) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathways [119,120].