CD274 and neoplasm: To further corroborate these findings, treatment of B7-H3 wild-type tumors in syngeneic mice with both the core-fucosylation inhibitor 2FF and anti-PDL1 mAb resulted in reduced tumor growth kinetics, decreased B7-H3 expression on tumor cells, and in increased infiltration of IFNγ+ NK cells as well as of IFNγ+ CD8 or CD4 T lymphocytes [65].