In vitro studies utilizing hepatocellular carcinoma cell lines demonstrated via a luciferase reporter technology that two microRNA, miR-34a and miR-122, play a negative role in FUT8 post-transcriptional regulation by interacting with the FUT8 3′-UTR and they ultimately can modulate glycosylation patterns [47]. The gene discussed is FUT8; the disease is hepatocellular carcinoma.