Combined with the motif finding results, these data (Figure S2) suggest that KDM6A might potentially cooperate with the TP53 family and the GRHL2 and FOSL2 transcription factors to drive gene expression associated with epithelial characteristics; meanwhile, coordination with transcription factors such as FOSL1, previously described to be involved in the invasive characteristic of bladder cancer [32,33], might contribute to the gene expression programs that drive tumorigenesis. Here, GRHL2 is linked to urinary bladder cancer.