HES1 and cancer: Among the genes occupied by KDM6A in the T24 cell line were Notch signaling family members, such as HES1 and TLE3 (as we have already shown in Figure 3), and genes that are deregulated in cancer, such as RUNX1, HHEX, and MET [40,41,42] (Figure 4A,B, Table S2).