Overall, higher sPD-L1 levels (>24.2 pg/mL) were linked to worse survival outcomes (OS: HR = 1.77, 95% CL = 0.72–4.37; PFS: HR = 2.16, 95% CL = 1.08–4.33) in the PC patients, while both sB7-H biomarkers showed an inverse correlation (Figure 2; Table S3). This evidence concerns the gene SPDL1 and pachyonychia congenita.