Conversely, FGF-mediated ERK1/2 signalling can correlate with the upregulation of TGF-β activity, as seen in other fibrosis models [14,49,74,75,76], as well as the current study where TGF-β-induced CLECs are associated with elevated ERK1/2-signalling. This evidence concerns the gene TGFB1 and fibrosis.