As the proteins encoded by disease-associated genes in repeat expansion disorders have low complexity regions composed by polyglutamine expansions (e.g., ATXN7 in SCA7 and CACNA1A/α-1ACT in SCA6), they are also prone to misfold, as shown for the abovementioned proteins (Table 1). This evidence concerns the gene CACNA1A and spinocerebellar ataxia 7.