These proteins are acute phase reactants such as: collectins, lactoferrin, haptoglobin, phospholipase A2, procalcitonin, C-Reactive protein or serum amyloid A. Furthermore, sepsis promotes an increase in other serum proteins with an opsonization function such as fibronectin and natural antibodies, mostly IgM, that produce circulating B lymphocytes. The gene discussed is LTF; the disease is Sepsis.