GHRL and Prader-Willi syndrome: Interestingly, in a recent work by Irizarry et al., the impact of carbohydrate restriction on hyperphagia, hormonal and metabolic balance, and adiposity in children with PWS was examined [52]; subjects consuming the low-carbohydrate diet were shown to have lower postprandial insulin levels, higher levels of fasting glucagon-like peptide 1 (GLP-1), increased gastric inhibitory peptide (GIP) concentrations, higher levels of postprandial GLP-1, and decreased ratio of fasting ghrelin to GLP-1 with respect to subjects on the low-fat diet [52].