Drug-induced liver injury (DILI) led to discontinuation of the ELX/TEZ/IVA treatment in one patient with CF and ALD, according to Stylemans et al. DILI is defined by one of the following thresholds: (i) ALT ≥ 5 times the upper normal limit, (ii) ALP ≥2 times the upper normal limit with an elevation of γ-GT or (iii) ALT ≥ 3 times the upper normal limit and elevation of TBIL ≥ 2 times the upper normal limit. The gene discussed is GPT; the disease is cystic fibrosis.