Of these, 90.7% (431/497) were diagnosed with the following three disorders: ALDH deficiency (69.4%), PNPO deficiency (13.2%), and PLPBP deficiency (9.2%) (Figure 1) [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95]. This evidence concerns the gene PLPBP and pyridoxal phosphate-responsive seizures.