However, the correlation was not confirmed in the study conducted by Xin et al. More precisely, CYP3A4*1B, CYP3A4*4, CYP3A4*5, and CYP3A4*6 variations did not have a significant effect in the appearance of CPP when 176 affected Chinese patients were examined, even though an association with pubertal onset was hypothesized [66]. Here, CYP3A4 is linked to central precocious puberty.