CASP3 and familial pancreatic carcinoma: In addition, the protein products resulting after proteolytic cleavage of DCLK1 by calpain and caspases 3/7 may also lead to pro-tumorigenic processes as recently demonstrated for the short isoforms of DCLK1 in colon, gastric, lung and pancreatic cancer [55,56,57,58,59].