Hyperglycemia, an increase in reactive oxygen species (ROS) production with cytosolic NADPH oxidase, and a deficiency in key antioxidants such as reduced glutathione (GSH) are considered to be the major damaging factors that are responsible for the structural and functional alterations in the retina, kidneys, nerves, and vessels in diabetics that ultimately lead to complications such as diabetic retinopathy (DR), diabetic nephropathy (DF), diabetic neuropathy (DN), diabetic angiopathy of the lower extremities (DA), and diabetic foot syndrome (DFS) [6,7,8,9]. Here, FMO5 is linked to diabetes mellitus.