TLR3 and infection: While TLR3, the double-stranded RNA (dsRNA) sensor that localizes in the endosomal surface, was expressed in control and infection EVs at both times (Supplementary Figure S2F and Figure 5A, respectively), TLR6 which recognizes lipopolysaccharide was significantly upregulated at 48 h in the infection-derived EVs compared to the control-derived EVs (* p = 0.03) (Supplementary Figure S2G and Figure 5B, respectively).