We also suggest that EVs could play a critical role in the CoV transmission and extracellular virus production in the host as they have packaged and expressed significantly higher levels of host cell receptor (ACE2) (Figure 3A–C), retroviral-specific protein (syncytin-1) (Figure 3D), and commercial coronavirus protein in the infection-derived EVs at different virus incubation times. The gene discussed is ACE2; the disease is infection.