CASP8 and infection: Here, the expression of an inflammatory caspase, caspase-1, was significantly upregulated at 48 h (* p = 0.049) (Supplementary Figure S2J and Figure 6B, respectively), and the level of an extrinsic apoptosis marker, caspase-8, was significantly elevated at 48 h but reduced at 72 h (*** p = 0.0004 and * p = 0.04, respectively) in the infection-derived EVs when compared to control-derived EVs (Supplementary Figure S2K and Figure 6C, respectively).