In addition, recent studies have revealed that BICC1 might be involved in the immune response in the tumor microenvironment by affecting immune cells, especially macrophages, and the overexpression of BICC1 was closely related to the poor prognosis in tumors such as gastric cancer and oral cancer, as well as multiple functional pathways such as focal adhesion and ECM-receptor interaction, which were also enriched in our study [46,47]. Here, BICC1 is linked to lip and oral cavity carcinoma.