THOP1 and Insulin resistance: Gewehr et al. found that the THOP1 null (THOP1−/−) mice gained 75% less body weight and showed neither insulin resistance nor non-alcoholic fatty liver steatosis (NAFLS) when compared with wild-type (WT) mice after 24 weeks of being fed a hyperlipidic diet (HD), and also observed a higher adipose tissue adrenergic-stimulated lipolysis in THOP1−/− mice [50].