CASP1 and metabolic dysfunction-associated steatotic liver disease: Tissue repair genes, such as fibroblast growth factor receptor 2 (FGFR2) and caspase 1 (CASP1), were hypomethylated and high-expressed, whereas a gene in one-carbon metabolism, methionine adenosyl methyltransferase 1A (MAT1A), which generates SAM, was hypermethylated and low-expressed in liver biopsies from patients with advanced NAFLD [12].