Importantly, TMEM100 is also a potential downstream target of FOXF1 using ChIP-seq analysis in mice with Foxf1 overexpression, suggesting that FOXF1 abnormalities may trigger the downregulation of this gene in ACDMPV patients [22]. The gene discussed is TMEM100; the disease is alveolar capillary dysplasia with misalignment of pulmonary veins.