While certain HERV-Ks, such as HERV-K17 on chromosome 17p13.1 (not HGCN: ERVK-17), show tissue-specific upregulation in prostate cells and downregulation in malignant cells [271,272], other members of the family, such as HERV-K-Mel (HML-6) on chromosome 16p11.1 [273] and HERV-K (HML-2) on chromosome 22q11.23 [238,274], display significantly higher expression in prostate cancer tissues and cell lines compared to healthy controls (Figure 9). The gene discussed is CLEC10A; the disease is Familial prostate cancer.