A detailed study of the HERV-K (HML-2) env knockdown through RNAi revealed the involvement of the viral gene in cellular pathways playing key roles in cancer (e.g., EGFR, TGF-β, NF-κB, MYC, p53, HRAS, KRAS, and MAPK1/3) (Figure 2) [75]. The gene discussed is TP53; the disease is cancer.