Conversely, Montesion et al. (2018) [68] identified two HERV-K (HML-2) LTRs (HGCN: ERVK-5 at position 3q12.3 and ERVK3-4 at 11p15.4) that had specifically increased promoter activity in breast cancer while decreased activity in immortalized human mammary epithelial cells. The gene discussed is CLEC10A; the disease is breast carcinoma.