Similar to the HERV-K (HML-2) Env-mediated regulation of cellular pathways shown in breast cancer cell lines, Ibba et al. (2018) were able to demonstrate that CRISPR-Cas9-facilitated knockout of HERV-K (HML-2) env leads to significant decrease in genes implicated in prostate cell transformation such as EGFR, NF-κB, SRSF1/2, and TDP-43 (HGNC: TARDBP) [281]. The gene discussed is CLEC10A; the disease is breast cancer.