Furthermore, HERV-Ec1 encoded on chromosome 1q31.1 has been observed to be located in antisense orientation to a cytosolic phospholipase A2 group IVA (PLA2G4A) that is dysregulated in many human tumors, and thus theorized to contribute to fine tuning of PLA2G4A and to have a potential role in oncogenesis of UCC [305] (see also HERVs in Testicular Cancer—The Governors of Tumor Suppressor Genes). This evidence concerns the gene PLA2G4A and neoplasm.