While Kaller et al. showed a positive correlation between PURPL RNA and TP53 target expression [227], just months before, Li et al. (2017) observed suppressive effects of PURPL RNA on TP53 through the binding of MYBBP1A (a TP53 stabilizer), leading to reduced proliferation and tumor growth in a mouse model [228]. The gene discussed is TP53; the disease is neoplasm.