A new non-contact dying-back injury mechanism theory of ALS recently postulated that irreversible intrafusal proprioceptive Piezo2 microinjury could be the primary damage [18,19] and that it is suggested to be a principal transcription activator [19], therefore letting the underlying genetic variants and cell-type-specific non-coding DNA variants become more apparent. The gene discussed is PIEZO2; the disease is amyotrophic lateral sclerosis.