It is notable that it is theorized that part of the miswired proprioceptive input in ALS is lost NMDA receptor activation spinally, with resultant increased NMDA PICs on the motoneurons, in addition to increased Na+ PICs due to the noncontact proprioceptive terminal Piezo2 irreversible microinjury [19,48] (see Figure 2). This evidence concerns the gene PIEZO2 and amyotrophic lateral sclerosis.