A current opinion piece postulated that the loss of these signaling pathways, leading to miswired proprioception, could be one reason why the primary pain is so heterogenous in ALS and why it used to be considered a painless disease, not to mention that the irreversible Piezo2 microinjury could constantly activate transcription pathways [19]. Here, PIEZO2 is linked to amyotrophic lateral sclerosis.