Correspondingly, the goal of our study was to reanalyze the potential pathogenic gene variants from our previous ALS study pertaining to the aforementioned pain signaling pathways, with a special focus on the L-type voltage-gated calcium channel, namely the Cav1.3 ion channel, encoded by the voltage-gated channel subunit alpha1 D (CACNA1D) gene. Here, CACNA1D is linked to amyotrophic lateral sclerosis.