By using the TLR2-dependent activation of the NF-κB pathway in a MyD88-dependent manner, SARS-CoV-2 S protein induces inflammation and promotes vWF transcription, causing in situ thrombosis, as vWF binds to platelets, neutrophils, and monocytes [113,114,115]. The gene discussed is VWF; the disease is Venous thrombosis.