Furthermore, selective CDK9 inhibition overcame TRAIL resistance by the suppression of anti-apoptotic proteins Fas-associating protein with a novel death domain (FADD)- like IL-1-converting enzyme (FLICE)-inhibitory protein (c-FLIP) and Mcl-1 in non-small cell lung cancer (NSCLC), pancreatic, ovarian and liver cancers [19]. Here, CASP8 is linked to non-small cell lung carcinoma.