In the remaining ten cell lines, three non-MLL-r myeloid leukemia carry a hypo- to hyper-triploid karyotype while four MLL-r AML, two non-MLL-r ALL, and one MLL-r ALL present a hypo- to near tetraploid karyotype, all with TERRA dosage response from changes in total telomere number (Table 1 and Figure 5B). Here, KMT2A is linked to acute myeloid leukemia.