Similar to endogenous MLL proteins, ectopic MLL-AF4, and MLL-AF9 fusion proteins have also shown an association with telomeric chromatin through their MLL N-terminus (MLL3AT and MLLDT) when conditionally expressed in non-MLL-r U-937 myeloid leukemia stable transfectants (Figure 1B,C). Here, AFF1 is linked to myeloid leukemia.