KMT2A and acute lymphoblastic leukemia: However, Fisher’s least significant difference (Fisher’s LSD) analysis showed significant differences in UUAGGG/28S levels between MLL-r and non-MLL-r ALL (p < 0.05) and between MLL-r ALL and MLL-r AML (p < 0.02), with 2.3- to 2.6-fold higher levels of UUAGGG repeat-containing RNA found in MLL-r ALL, respectively (Figure 2B).