Assuming rRNA dosage compensation in all polyploid leukemia cell lines analyzed, transcriptome-normalized TERRA levels divided by ploidy [(UUAGGG/28S/MTL)/ploidy] confirmed significantly higher TERRA levels per telomere in MLL-r ALL than non-MLL-r ALL (3.2-fold; p < 0.0001) or MLL-r AML (2.3-fold; p < 0.0005) (Figure 5C). The gene discussed is KMT2A; the disease is acute myeloid leukemia.