Our ChIP analysis has revealed an association of MLL proteins with telomeric chromatin in both non-MLL-r and MLL-r leukemia, with ectopically expressed MLL-AF4, MLL-AF9, and MLLN deletion mutants displaying the binding of MLL-FPs to telomeres through their MLL N-terminus, in support of potential deregulated telomere transcription in MLL-r leukemia. Here, MLLT3 is linked to leukemia.