In our previous work, we achieved to show that an increased proportion of patients diagnosed with MS (43%) were positive for the presence of IgG antibodies against seven coagulation serine proteases, i.e., factor VIIa (FVIIa), thrombin, prothrombin, FXa, FXII, protein C, and plasmin, also demonstrating that such molecules can be correlated with advance disability status and progression of the disease [17]. This evidence concerns the gene F2 and myeloid sarcoma.