DRD2 and schizophrenia: In agreement with this earlier study, a further SPECT study with [123I]iodobenzamide showed that there was a significant negative correlation between low striatal D2R binding potential at baseline (which was considered to indicate higher synaptic dopamine levels) and amelioration of positive symptoms after a 6-week treatment with amisulpride in antipsychotic-naïve schizophrenia patients [180].