The circulating value of chitotriosidase and neopterin showed no significant differences when smokers were compared with non-smokers, neither in the CRC group (Mann-Whitney test: p-value = 0.9626 for chitotriosidase and 0.6221 for neopterin) nor in C group (Mann-Whitney test: p-value = 0.9219 for chitotriosidase and 0.2686 for neopterin). The gene discussed is CHIT1; the disease is colorectal carcinoma.