The objectives of the current study were to assess: (i) the variability of circulating chitotriosidase and neopterin in patients with CRC as compared to controls; (ii) the changes of circulating values of chitotriosidase and neopterin after standard treatment in patients with CRC; (iii) the association of chitotriosidase and neopterin plasma levels with current CRC markers. The gene discussed is CHIT1; the disease is colorectal carcinoma.